Understanding Albumin/Globulin Ratio: Normal vs Optimal Ranges

?What is Albumin/Globulin Ratio?

The A/G ratio (albumin to globulin ratio) is calculated by dividing serum albumin by serum globulin. It reflects the balance between the liver's synthetic function (albumin) and immune activity (globulins). A ratio below 1.0 is particularly significant.

!Why It Matters

A reversed A/G ratio (below 1.0) is seen in liver cirrhosis, autoimmune diseases, chronic infections, and paraproteinaemias. A very high ratio may indicate low globulins from immune deficiency. Interpreting the A/G ratio alongside individual albumin and globulin values provides a fuller picture of liver and immune function.

Reference Ranges

Lab normal ranges may vary between laboratories. Optimal and longevity targets are based on research literature and should be interpreted with your physician.

Symptoms of Imbalance

• No direct symptoms from the ratio itself

How to Improve Your Levels

• 1Treat underlying liver disease, which lowers albumin and reduces the A/G ratio
• 2Address chronic infection, inflammation, or immune conditions that raise globulin
• 3Ensure adequate protein intake and nutritional status to support albumin
• 4Investigate a persistently low A/G ratio with serum protein electrophoresis

When to Test

Calculated automatically from standard liver function tests.

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