Understanding A/G Ratio: Normal vs Optimal Ranges

?What is A/G Ratio?

The A/G ratio (albumin-to-globulin ratio) is a calculated value from a comprehensive metabolic panel reflecting the balance between liver-produced albumin and immune-related globulin proteins. It is a sensitive screen for hepatic synthetic dysfunction and immune dysregulation.

!Why It Matters

A low A/G ratio may indicate liver cirrhosis, chronic hepatitis, nephrotic syndrome, or autoimmune conditions causing elevated globulins. The ratio aids in narrowing differential diagnoses when serum proteins are abnormal and guides decisions about further testing such as protein electrophoresis.

Reference Ranges

Lab normal ranges may vary between laboratories. Optimal and longevity targets are based on research literature and should be interpreted with your physician.

Symptoms of Imbalance

• Oedema or fluid retention from low albumin
• Fatigue, jaundice, or abdominal swelling from liver disease
• Signs of chronic infection or autoimmune disease when globulins are elevated

How to Improve Your Levels

• 1Optimise liver health through a balanced diet and avoiding alcohol excess
• 2Adequate protein intake to support albumin synthesis
• 3Treat underlying conditions causing globulin elevation

When to Test

Calculated automatically with comprehensive metabolic panel; retest every 6–12 months if abnormal.

Related Biomarkers