Understanding AA/EPA Ratio: Normal vs Optimal Ranges

?What is AA/EPA Ratio?

The AA/EPA ratio measures the balance between arachidonic acid (AA, an omega-6 fatty acid that promotes inflammation) and EPA (eicosapentaenoic acid, an omega-3 fatty acid that is anti-inflammatory). A lower ratio indicates a more anti-inflammatory fatty acid balance.

!Why It Matters

The AA/EPA ratio is considered by many researchers to be a better measure of inflammatory fatty acid balance than either omega-6 or omega-3 levels alone. Japanese longevity researchers have linked low AA/EPA ratios (around 1.5–3) with the low cardiovascular disease rates seen in Japanese populations who eat fatty fish regularly. High AA/EPA ratios (above 10–15) are associated with greater inflammatory state and higher cardiovascular risk.

Reference Ranges

Lab normal ranges may vary between laboratories. Optimal and longevity targets are based on research literature and should be interpreted with your physician.

Symptoms of Imbalance

• High ratio: associated with greater inflammatory burden, joint pain, cardiovascular risk

How to Improve Your Levels

• 1Increase EPA through fatty fish or fish oil supplements
• 2Reduce arachidonic acid by limiting red meat and processed foods
• 3Replace omega-6-rich oils with olive oil and reduce overall vegetable oil consumption

When to Test

As part of a comprehensive fatty acid panel. Requires specialised testing not widely available in India.

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