Understanding DGLA: Normal vs Optimal Ranges

?What is DGLA?

Dihomo-gamma-linolenic acid (DGLA) is an omega-6 fatty acid metabolite formed from GLA. It can be converted either to anti-inflammatory series-1 prostaglandins (PGE1) or to arachidonic acid. The balance between these pathways determines whether DGLA has anti-inflammatory or pro-inflammatory effects. PGE1 from DGLA promotes vasodilation and reduces platelet aggregation.

!Why It Matters

DGLA levels reflect the functional activity of omega-6 fatty acid desaturation pathways. Adequate DGLA with sufficient EPA (which blocks conversion to AA) maximises anti-inflammatory PGE1 production. DGLA is implicated in cardiovascular health, immune regulation, and skin inflammation. It is included in advanced fatty acid profiles to assess omega-6 pathway function.

Reference Ranges

Lab normal ranges may vary between laboratories. Optimal and longevity targets are based on research literature and should be interpreted with your physician.

Symptoms of Imbalance

• Low DGLA: may impair anti-inflammatory prostaglandin E1 production

How to Improve Your Levels

• 1GLA supplementation (evening primrose oil, borage oil) raises DGLA levels
• 2Concurrent EPA supplementation prevents DGLA-to-AA conversion
• 3Cofactors: zinc, B6, magnesium, vitamin C support GLA-to-DGLA conversion

When to Test

As part of advanced omega fatty acid profiling; inflammatory and autoimmune disease assessment.

Related Biomarkers