Understanding DHEA-S: Normal vs Optimal Ranges

?What is DHEA-S?

DHEA-S (dehydroepiandrosterone sulphate) is produced by the adrenal glands and serves as the precursor to both androgens (testosterone, DHT) and oestrogens. It is the most abundant circulating steroid hormone and its levels naturally peak in the mid-20s and decline progressively with age — often by 80–90% by age 70.

!Why It Matters

DHEA-S decline with age correlates with many features of biological ageing — reduced muscle mass, bone density, libido, immune function, and cognitive performance. Some studies suggest that maintaining higher DHEA-S levels is associated with longevity and reduced cardiovascular disease. DHEA supplementation is controversial but increasingly studied in ageing and functional medicine.

Reference Ranges

Lab normal ranges may vary between laboratories. Optimal and longevity targets are based on research literature and should be interpreted with your physician.

Symptoms of Imbalance

• Low DHEA-S: fatigue, reduced libido, decreased motivation, DHEA deficiency symptoms in adrenal insufficiency

How to Improve Your Levels

• 1DHEA supplementation (25–50 mg/day) raises DHEA-S levels — use under medical supervision
• 2Reduce chronic stress — cortisol suppresses DHEA production via 'pregnenolone steal'
• 3Exercise, sleep optimisation, and vitamin D support adrenal function

When to Test

Not routinely tested. Consider in fatigue workup, hormonal assessment, suspected adrenal insufficiency, or as part of a comprehensive longevity panel.

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