Understanding Myeloperoxidase: Normal vs Optimal Ranges

?What is Myeloperoxidase?

Myeloperoxidase (MPO) is an enzyme produced by neutrophils and monocytes that generates reactive oxygen species and contributes to inflammatory responses. Elevated MPO levels can indicate active inflammation or oxidative stress in the body and may be associated with cardiovascular risk, infection, or chronic inflammatory conditions.

!Why It Matters

MPO is a marker of neutrophil activation and inflammatory burden that may help assess cardiovascular risk independent of traditional cholesterol markers. Elevated levels can suggest ongoing inflammation or immune activation, which could contribute to atherosclerosis, tissue damage, or increased susceptibility to infection.

Reference Ranges

Lab normal ranges may vary between laboratories. Optimal and longevity targets are based on research literature and should be interpreted with your physician.

Symptoms of Imbalance

• Persistent fatigue
• Frequent infections
• Joint or muscle pain
• Chest discomfort or palpitations
• Chronic inflammation-related symptoms

How to Improve Your Levels

• 1Reduce intake of processed foods and refined carbohydrates that promote inflammation
• 2Increase consumption of antioxidant-rich foods (berries, leafy greens, fatty fish)
• 3Engage in regular moderate aerobic exercise
• 4Manage stress through meditation, yoga, or other relaxation techniques
• 5Ensure adequate sleep (7–9 hours nightly)
• 6Consider omega-3 supplementation or increase fatty fish intake

When to Test

Test MPO when screening for cardiovascular risk, evaluating chronic inflammatory conditions, investigating recurrent infections, or monitoring response to anti-inflammatory treatment.

Related Biomarkers